RNA Vaccine production System

Technical specifications: Methods of analysis optical density, endpoint, kinetics, fixed time, nonlinear, two-wave, turbidimetry Light source halogen lamp (12 V, 20 W) with a slow start system to increase the service life Built-in interference light filters 340, 405, 505, 546, 578, 630nm; spectral half-width 12 nm The optical density measurement range is 0-2.5 E.O.P. The measurement error of optical transmission is not more than 1 % Memory of 100 measurement programs Temperature control of the measuring cell built-in thermostat with Peltier element: 25, 30, 37 ° C; accuracy ± 0.2 ° C Sample incubation thermostat external, for 16 vials The volume of the flow cell is 32 µl Consumption of the working reagent from 250 µl Built-in matrix printer, printing on plain paper with a tape width of 56 mm Liquid crystal display: 4 lines of 20 characters each Productivity of up to 100 analyses/hour by the endpoint method Dimensions and weight no more than 355x355x185 mm; 8.5 kg

Technical characteristics: Consumption of working reagents 1.0–2.0 ml – for standard filling cuvette K10 from 400 ml – for photometric techniques Filters for photometer mode, nm built-in interference filters 340, 405, 505 ,545, 575, 630 spectral half-width of 10 nm Filters for fluorimeter and chemiluminometer modes on request, in the spectral range of 270-850 nm Chemiluminescence channel sensitivity 10000 photons per second Optical density measurement range, E.O.P. 0-2.20 Photometric channel accuracy, %2 Memory of 100 measurement programs Temperature control of the measuring cell (for photometer and chemiluminometer modes) built-in thermostat on the Peltier element: 25, 30, 37 OC; accuracy ± 0.2 oC Volume of the flow cuvette, mkl 80 Pump type (only for photometer mode) peristaltic pump with programmable liquid supply volume Productivity, analyses/hour up to 100 (by the endpoint method) Information output liquid crystal display and personal computer Power supply, 220 ± 22 Dimensions, mm 430x350x160 Weight, kg 10

Implements a thermogravimetric (air-thermal) method for determining the mass fraction of moisture, based on measuring the mass of the sample of the analyzed substance before and after drying, followed by calculating the values of the mass fraction of moisture. Air-thermal measuring installations ASESH-8 are registered in the State Register of Measuring Instruments under No. 58526-14, have a certificate of approval of the type of measuring instruments OC.C.31.005 And No. 56847.The installations undergo initial verification and have the appropriate certificate. General characteristics: - The presence of two independent drying chambers. - Possibility of simultaneous determination of humidity of 12 samples: Each drying chamber of the installation consists of 6 independent cells. You can put 2 buckets in each cell. Total capacity of the ASES Installation-8-2 – 24 bucs. - Convenient access to the cells of the drying chamber: On the front side of the cabinet there are four doors for access to the cells. - Natural ventilation: The absence of rotating elements ensures absolute noiselessness of operation and a long service life. - Built-in timer: The ASESH-8-2 installation has 4 timers, by means of which the end of the drying process is monitored in each section with the output of an audible signal and a light indication. - The output to the operating mode is 30 minutes: The power of air-thermal installations is 1200 watts. When entering the operating mode, the power consumption is the same as that of similar cabinets with low power. SCOPE OF DELIVERY : 1. Installation of ASESH-8-2 2. AO-3 cooler 3. Auxiliary accessories 4. Air-heat control unit: 5. Interface unit for connecting a personal computer with a scale (available on request); 6. software for processing and archiving measurements of humidity determination data; The program allows you to: Set the operating temperature in the chambers via a personal computer Set the necessary parameters of the sample drying process according to the selected method Display all current processes (predrying, drying, cooling) and parameters (temperature, time) during the tests. To monitor the process by means of an electronic timer with the output of an audible signal. Record all weighing results. Perform humidity calculations in accordance with standardized methods. To calculate the humidity with pre-drying, the program uses formulas that allow you to get an accurate result. Archive and print test results. According to the test results of FSUE "UNIIM", it is recommended to use a laboratory mill of the BLIZZARD series for sample preparation. SCOPE OF APPLICATION: 1. Crop production, agriculture and forestry. 2. Products of meat, dairy, fish, flour-milling, feed and microbiological industries. 3. Food industry products. 4. Cellulose, paper, cardboard and products made from them. 5. Medicines, chemical and pharmaceutical products and medical products. 6. Building materials. 7. Products of the logging and sawmilling and woodworking industry. 8. Ground, soils, mineral fertilizers. Technical specifications: The measurement range of the mass fraction of moisture, % from 0.5 to 80 Operating temperature range, °C from 45 to 160 The error of setting and maintaining the temperature in the working area, ° C, not more than 2.0 Limits of permissible absolute error, % ± 0.5 Power consumption, V• A, not more than 1200 Overall dimensions, mm 240 × 260 × 640 Overall dimensions of the cell, mm 75 x 40 x 165 (depth) Weight, kg 28.4

The lowest cost and most compact version of the LumoTrace® Optical Imaging System manufactured by Abisens LLC for sensitive bioluminescence detection. The compactness and low price of the LumoTrace®Lite imaging system are due to the fact that it allows only bioluminescence to be recorded (older models, in addition to bioluminescence, allow fluorescence to be recorded, and are also modular, which provides them with the opportunity to upgrade). Despite its compactness and relatively low price, this model is equipped with a new highly sensitive digital camera HICMOS manufactured by Abisens LLC, which allows recording ultra-small amounts of phosphor both in laboratory animals in vivo and in vitro experiments. The device is an indispensable tool for conducting preclinical studies on the way to the introduction of advanced drugs, in the implementation of non-invasive monitoring of the development of socially significant diseases, monitoring the effectiveness of immuno- and gene therapy,

The Kjeldahl method is one of the most accurate methods for determining nitrogen and protein in a wide group of products, but, unfortunately, it has a number of significant drawbacks - these are low speed, a large number of possible losses during the analysis, bulky equipment, and the use of aggressive reagents. Sibagropribor Holding presents KELTRUN (KELTRUN) - a set of equipment for carrying out a complete analytical cycle according to the Kjeldahl method, which will allow: • to increase the speed of analyzes (high speed of distillation and ashing, simultaneous processing of several samples); • ensure the safety of personnel (high quality of reaction vessels, effective absorption of acid vapors by the exhaust system, additional protection of personnel in emergency situations); • reduce possible losses in the analysis process; • improve the reproducibility of results. «KELTRAN» (KELTRUN) will allow you to determine nitrogen / protein in the widest list of substances: • food products: dairy, cereals, meat, cereals, etc.; • feed and compound feed; • fertilizers; • water, drinks, beer; • soil, bottom sediments, sediment samples, activated sludge; • crude oil, lubricants; • various chemicals; • alcohol content in wines, musts and spirits; • etc. The set of equipment «KELTRAN» (KELTRUN) allows you to analyze according to GOST and determine the nitrogen content in the range of 0.02 - 99.00%. Composition of the complex «KELTRAN» (KELTRUN): - Digestor; - Distiller; - Scrubber (*not included in the price of the complex); - Titration unit: manual, semi-automatic or automatic (*not included in the price of the complex); Warranty - 1 year. Important feature! In many distillers (made in China and others), when used, alkali passes through a valve-type pump, with a low production resource (sometimes the resource is enough for only 3 months). In the distiller of our production, the alkali passes through a RELIABLE PERISTALTIC PUMP, this ensures a long service life of the distiller! Package options Cost (including VAT): Digestor, Distiller, Water jet pump 379,400 rubles; Digestor, Distiller, Water jet pump, Scrubber 434,700 rubles; Digestor, Distiller, Water jet pump, Manual titration unit 396,900 rubles; Digestor, Distiller, Water jet pump, Scrubber, Manual titration unit 452,200 rubles; Digestor, Distiller, Water jet pump, Kit «Titrion-pH» (c2) 605,400 rubles; Digestor, Distiller, Water jet pump, Scrubber, «Titrion-pH» kit (c2) 660,700 rubles.

Intensity: up to 2,500 rpm. Volume: 85dB Weight: 30 kg Dimensions: 33*33*29 (WxDxH) Timer: up to 30 min. Digital display: no Intensity adjustment: no Temperature adjustment: no Equipment: -Device -Key "Baikal" -A set of holders for test tubes (x6 (for 1.5-2 ml tubes) - 2 pcs., x3 (for 5-15 ml tubes, 2 pcs.). -A set of steel balls, 100 pcs.

We offer expert laboratories of physicochemical methods of analysis a gas chromatograph with a quadrupole mass spectrometric detector «MAESTRO-αMS». Quadrupole GC-MS «MAESTRO-αMS» is in demand for targeted research (screening) and non-targeted search. In targeted studies, it is necessary to detect given target compounds in samples of various nature and origin at the level of residual amounts, for example, several picograms of the target compound in the injected 1 μl of liquid sample. Most often, targeted research is carried out in the following areas of laboratory screening: ecology, food safety, clinical monitoring, narcology, doping control, production control of various raw materials. In targeted studies, it is often required not only to confirm the presence of a compound in a sample, but also to determine the level of its content quantitatively, since both the list of target compounds and the permissible level of their presence in the sample are specified by regulatory documents. Quantitative analysis requires standards for the substances you are looking for. When conducting a non-target search, as a rule, it is required to analyze a sample of unknown composition, in other words, to find as many compounds as possible in the sample and identify (identify) each of them. Since the identification of a detected compound is carried out by comparing its experimental mass spectrum with the spectrum of a pure substance obtained under standard conditions, this task requires reference libraries of mass spectra of pure substances, as well as tools for working with mass spectra, for example: algorithms for cleaning experimental mass spectra from background and spectral noise (mass spectrum deconvolution algorithms), library search and comparison algorithms. An off-target search is called a qualitative analysis, since the researcher is primarily interested in the list of detected substances, and not in the quantitative assessment of their content in the sample. When creating MAESTRO-αMS, we took into account our own many years of experience in operating imported analogues. We have made the device inexpensive. We have made the device compact: The modern design of the device made it possible to make the MAESTRO-αMS really compact, so that the device occupies the smallest possible area on the laboratory table. The layout of the device allows you to remove the ion source on the front flange for cleaning and replacing the cathodes, if necessary. We have reduced the cost of operation: When developing the MAESTRO-αMS, we sought to increase the resistance of the device to sample matrices and use a minimum of consumable materials in order to eliminate downtime for maintenance and replacement. As a result, we have created an extremely stable ion source and a perpetual photomultiplier detector. We have created special software: Even at the first acquaintance with the software, it becomes obvious that being in the window of each button and each parameter to be changed is expedient and logical. Our software product was created for the convenience of the operator, so we implemented the necessary and eliminated the unnecessary. We used the principle of one active window, in which the operator moves sequentially step by step, performing hardware settings, setting the data collection method, subsequent processing algorithms, templates for presenting the results. MAESTRO-αMS offers a wide range of scanning modes, built-in algorithms for working with mass spectral data, convenient unloading of initial data arrays for their processing in specialized software packages, graphics export for presentations and scientific publications. You can use several libraries of mass spectra at the same time, or create your own for your typical tasks. Finally, we provide a 5-day training course for professionals who want to understand the theoretical foundations of the method and their implementation in the hardware of modern quadrupole GC/MS. The volume and depth of presentation of the material from the developers of the device is intended to lay the foundation for the effective use of «MAESTRO-αMS» in the future. Some technical characteristics of MAESTRO-αMS: • Instrumental detection limit (SIM, OFN @272 m/z ) < 10 fg; • Scan modes: scan for selected ions, full scan in a given mass range, combined scan mode; • The number of simultaneously connected libraries of mass spectra is at least 10.

Functionality 1. Centrifugation function (300 - 4000 rpm). 2. Shaking function (forward-reverse rotation with a frequency of 2 sec.). 3. Mixing in the flask (up to 400 rpm). 4. Mixing in a test tube (500 rpm). 5. Full loading: 12 plastic tubes of the Eppendorf type with a volume of 1.5 ml or 2 ml Safety 1. Blocking operation when the lid is open. 2. Stops working when opening the lid. 3. Stops working when the mains voltage disappears; it does not restart when the mains voltage appears again. 4. Automatic shutdown after 60 minutes. 5. Low-voltage power supply (+24V). Ergonomics 1. Simple and intuitive arrangement of controls. 2. RPM or linear g-load are displayed on the readout.

Overall dimensions: 550x230x350 mm Weight (without computer): ~17 kg Power consumption: up to 200 watts Warranty service : 1 year   Detector Two-beam spectrophotometer Spectral range – 190-360 nm Simultaneous detection at 1-8 wavelengths Cell volume – 1.2 µl Noise <0.0001 E.O.P. at 250 nm Drift <0.00005 E.O.P./hour at 250 nm Column Ø2x75 mm stainless steel The efficiency of the column is up to 6000 theoretical plates Thermostat Solid-state electric Set temperature from 35 to 90°C The discreteness of the temperature setting is 1 °C Temperature control error ±0.3°C      Pump Two-pronged, gradient The feed rate is from 5 to 1000 µl/min, the maximum pressure is 70 atm . The gradient is formed from 1 to 20 linear sections Automatic doser Automatic, programmable Number of test tubes – 46 The number of analyses in the series is from 1 to 200 The dosed volume is from 1 to 99 µl Test tubes made of glass with a volume of 200 µl Polyethylene tube stoppers Software OS: Windows® XP/7/10 Milichrome A-02™, Multichrome™, Alphachrome, Alphaspectrum