SajStorLab

Vascular Endothelial Growth Factor is one of the key regulators of angiogenesis. The most important role in the human body is played by a protein of the VEGF family called VEGF-A. VEGF-A is a 45 kDa glycoprotein homodimer and plays a key role in chemotaxis and angioblast differentiation, endotheliocyte (EC) proliferation, vasculogenesis, and vascular remodeling. As a result of alternative splicing or proteolytic cleavage, 4 main isoforms of VEGF-A are formed, consisting of 121, 165, 189, or 206 amino acid residues.

IL-7 is a hematopoietic growth factor that stimulates T-lymphocyte differentiation and maintains homeostasis of naive T-cells and memory T-cells. It is possible that human IL-7 is involved in the regulation of postnatal development of B-lymphocytes. IL-7 plays an important role in the development of secondary lymphoid organs.

The family of interferons (IFNs) are glycoprotein proteins that have a wide range of biological activity, including antiviral, antitumor, and also exhibit antiproliferative and proapoptotic properties. There are three known types of interferons: type I IFN / type I IFN (α, β, ω, τ, κ, ˜, and δ), type II IFN / type II IFN (γ), and type III IFN / type III IFN (λ1 (IL-29), λ2 (IL-28A), λ3 (IL-28B)). The classification of interferons by type is based on their interaction with the corresponding cellular receptors. Type I and II IFN receptors are present on the surface of most human cells, while type III IFN receptors are highly expressed on hepatocytes, but absent on the surface of microvascular endothelial cells, adipocytes, fibroblasts, and cells of the central nervous system.

IL-15 is a pleiotropic cytokine. It is essential for the development, survival, and activation of NK cells. Participates in the induction of cytotoxic effector cells. Acting as an interleukin-2 antagonist, IL-15 contributes to the maintenance of CD8+ T memory cells and the maintenance and survival of CD4+ and CD8+ T lymphocytes. Acts on a number of other cells.

Epidermal growth factor is a polypeptide that stimulates the differentiation and growth of epithelial cells.

Human Serum Albumin (HSA) is the main human plasma protein and has many physiological properties due to its unique structure.

Stem cell factor is a growth factor produced mainly by fibroblasts and endothelial cells. The cytokine SCF plays an important role in the survival and proliferation of hematopoietic cells, melanocytes and germ cells, their migration and differentiation.

Tumor Necrosis Factor α, TNFα is a pleiotropic pro-inflammatory cytokine produced by monocytes, macrophages, fibroblasts, and astrocytes. One of the proteins of the acute phase of inflammation. It has antitumor activity. TNFα is involved in the pathogenesis of a number of diseases.

Vascular Endothelial Growth Factor is one of the key regulators of angiogenesis. The most important role in the human body is played by a protein of the VEGF family called VEGF-A. VEGF-A is a 45 kDa glycoprotein homodimer and plays a key role in chemotaxis and angioblast differentiation, endotheliocyte (EC) proliferation, vasculogenesis, and vascular remodeling. As a result of alternative splicing or proteolytic cleavage, 4 main isoforms of VEGF-A are formed, consisting of 121, 165, 189, or 206 amino acid residues.

Interleukin-6 is a cytokine that is secreted in response to infection or tissue damage and induces the production of proteins of the acute phase of inflammation, stimulates hematopoiesis and the immune response.

Placental Growth Factor, PlGF is a protein from the family of vascular endothelial growth factors (VEGF), synthesized mainly by trophoblast cells, stimulating the development of placental vessels and proliferation of trophoblast cells.

Nojin is a protein involved in the development of various tissues, including bone, muscle and nerve. It is an antagonist of bone morphogenetic proteins (MBPs). Noggin has been implicated in a number of pathological conditions.