SajStorLab

Stem cell factor is a growth factor produced mainly by fibroblasts and endothelial cells. The cytokine SCF plays an important role in the survival and proliferation of hematopoietic cells, melanocytes and germ cells, their migration and differentiation.

Interleukin 2 is a cytokine that has pleiotropic properties and regulates several functional responses of target cells. It induces T cell proliferation (acting as a growth factor) and effector T cell synthesis of cytokines, thus providing an effector response. IL-2 is also a key factor in the development, expansion and maintenance of regulatory T cells, which plays an important role in balancing and regulating the immune response and preventing autoimmune diseases. Interleukin 2 is also capable of activating a number of other cells (B-lymphocytes, NK cells, neutrophils), triggering the processes of autivation and expression of receptor genes in them, the synthesis of effector molecules, and phosphorylation pathways for many intracellular proteins.

Granulocyte-macrophage colony-stimulating factor is a hematopoietic growth factor and an immune response modulator. Human GM-CSF is a 127 amino acid monomeric protein with two glycosylation sites. The variability in glycosylation results in differences in molecular weight ranging from 14 kDa to 35 kDa. Non-glycosylated and glycosylated GM-CSF show similar activity in vitro.

The family of interferons (IFNs) are glycoprotein proteins that have a wide range of biological activity, including antiviral, antitumor, and also exhibit antiproliferative and proapoptotic properties. There are three known types of interferons: type I IFN / type I IFN (α, β, ω, τ, κ, ˜, and δ), type II IFN / type II IFN (γ), and type III IFN / type III IFN (λ1 (IL-29), λ2 (IL-28A), λ3 (IL-28B)). The classification of interferons by type is based on their interaction with the corresponding cellular receptors. Type I and II IFN receptors are present on the surface of most human cells, while type III IFN receptors are highly expressed on hepatocytes, but absent on the surface of microvascular endothelial cells, adipocytes, fibroblasts, and cells of the central nervous system.

Thrombopoietin is a glycoprotein hormone synthesized mainly in the liver, the main physiological regulator of platelet production. Participates in the development of precursors of other blood cells. TPO and other TPO receptor agonists are promising therapeutic agents.

Human Serum Albumin (HSA) is the main human plasma protein and has many physiological properties due to its unique structure.

Anti-c-Myc Tag antibody - mouse monoclonal antibodies to the Myc-tag epitope corresponding to amino acid residues 410-419 (EQKLISEEDL) in the C-terminal domain of human c-Myc. These antibodies are used in immunological methods for the detection of recombinant Myc-tag proteins, as well as for the purification of proteins by affinity chromatography.

Interleukin 3 is a cytokine, a multipotent colony-stimulating hematopoietic factor, produced mainly by activated T-lymphocytes. The main function of IL-3 is participation in the differentiation and proliferation of myeloid precursor cells. IL-3 is involved in the pathogenesis of a number of diseases, including hematological tumors. IL-3 is a therapeutic agent in the treatment of conditions associated with insufficient hematopoietic function of the bone marrow.

Human hepatocyte growth factor - participates in the processes of morphogenesis and regeneration, stimulation of the survival of hepatocytes, tubular cells of the kidneys, neurons.

Fibroblast growth factor-2 is a member of the fibroblast growth factor family. It has mitogenic activity against target cells, is a neurotrophic factor, participates in the regulation of angiogenesis, individual development, tissue regeneration, reproduction and pathogenesis of a number of diseases, including malignant tumors.

Nojin is a protein involved in the development of various tissues, including bone, muscle and nerve. It is an antagonist of bone morphogenetic proteins (MBPs). Noggin has been implicated in a number of pathological conditions.

Interleukin 4 is a pleiotropic cytokine that regulates the cellular and humoral immune response and is involved in the processes of proliferation, differentiation, and activation of cells of various types. IL-4 is expressed by activated T lymphocytes, mast cells, dendritic cells, NKT cells, basophils, eosinophils. The epithelium and tumor cells are sources of IL-4 in tissues.